Exchange Rate. Money Management . It is also regarded as the value of one country’s currency in relation to another currency. In this case it is said that the price of a dollar in relation to yen is ? Wild Card Lora Leigh Epub Download For MacThe spot exchange rate refers to the current exchange rate. The forward exchange rate refers to an exchange rate that is quoted and traded today but for delivery and payment on a specific future date. In order to determine which is the fixed currency when neither currency is on the above list (i. This reduces rounding issues and the need to use excessive numbers of decimal places. There are some exceptions to this rule: for example, the Japanese often quote their currency as the base to other currencies. It is the ratio of the number of units of a given country's currency necessary to buy a market basket of goods in the other country, after acquiring the other country's currency in the foreign exchange market, to the number of units of the given country's currency that would be necessary to buy that market basket directly in the given country. Aug 24, 2017 Chelsea Cain – Furie: Aug 24, 2017 Belinda Bauer – Mädchenbeute: Aug 24, 2017 Wladimir Kaminer – Liebesgrüsse aus Deutschland. Find the best eBooks and eBook deals, and browse our 99 cent eBooks. Add to your online library, and download a best seller or classic for NOOK, Apple or Android. Shop Barnes & Noble for Romance, NOOK Books. The Bride’s Matchmaking Triplets. Elizabeth forced her shaking hand to steady on the spoon. Updated daily, these lists feature the most recent arrivals to the library. Subscribe to get recommendations from Spokane Public Library delivered to your inbox. An Archive of Our Own, a project of the Organization for Transformative Works. There are various ways to measure RER. For example, the purchasing power of the US dollar relative to that of the euro is the dollar price of a euro (dollars per euro) times the euro price of one unit of the market basket (euros/goods unit) divided by the dollar price of the market basket (dollars per goods unit), and hence is dimensionless. This is the exchange rate (expressed as dollars per euro) times the relative price of the two currencies in terms of their ability to purchase units of the market basket (euros per goods unit divided by dollars per goods unit). If all goods were freely tradable, and foreign and domestic residents purchased identical baskets of goods, purchasing power parity (PPP) would hold for the exchange rate and GDP deflators (price levels) of the two countries, and the real exchange rate would always equal 1. 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As usual, this is a work in progress as I know there are TONS more books in this genre. It is extremely rare that individual traders actually see the foreign currency. Instead, they typically close out their buy or sell commitments and calculate net gains or losses based on price changes in that currency relative to the dollar over time. The participants include large banks, multinational corporations, governments, and speculators. Individual traders comprise a very small part of this market. Because of the volatility in the price of foreign currency, losses can accrue very rapidly, wiping out an investor’s down payment in short order. It has to pay suppliers in other countries with a currency different from its home country’s currency. The home country is where a company is headquartered. The firm is likely to be paid or have profits in a different currency and will want to exchange it for its home currency. 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A major evolution of the steel cage, the new structure came into play at Badd Blood in a WWE Championship Match between Shawn. They have survived all 5 major mass extinctions, including the Permian one that wiped out most life on Earth. Since sharks are made of cartilage, they do not preserve very well. Usually only their dermal denticles (modified scales) and teeth readily fossilize. Because of this, their origins are fragmentary, yet we have a good idea of when they first appeared. The First Sharks - Ordovician Beginnings. The first sharks come to us from the Ordovician radiation event. The Ordovician radiation, or more impressively called the . During this biodiversification event, Earth experienced an unprecedented explosion of new classes, orders, families, genera, and species, including the chondrichthyes. It was evolution on steroids. The first shark- like fossils found were denticles, discovered in the Harding Sandstone of Colorado (Samson et al 1. Carmichael Sandstone of the Stokes Formation in Australia (Young 1. However, it was unclear if these fossils were from actual sharks, or shark like fish. Later, this dentine that forms the denticles found in the Harding Sandstone was found on the fin scales of the small spotted catshark (Zerina 2. As a result it was concluded the world's oldest sharks were in the Harding and Carmichael Sandstone; however these sharks were never named. In 2. 01. 2, Sansom et al. This time a new shark genus and species was erected to name the animal, Tantalepis gatehousei (Sansom et al 2. An interesting thing to note is only dermal denticles, and not teeth, have been found. Jawed fish were just developing at this time. It appears teeth developed later. So, according to the fossil. Many more shark denticles have been found. Silurian outcroppings. Some of the first come from the Upper Silurian Pitchi- Shui Formation in Tuva (Southern Siberia). They are described by Karatajute & Talimaa (1. Elegestolepis. Since only scales have been found of Elegestolepis, not much is known about the sharks appearance. Fish, including sharks became more common and much more diverse. This is why the Devonian period is called the . The world's oldest complete shark fossil is of a specimen called Doliodus problematicus. It is Early Devonian (4. Campbellton Formation in New Brunswick, Canada (Miller et al 2. The best- preserved specimens of complete fossilized Devonian sharks are from the Late Devonian Cleveland Shale. The Cleveland Shale. There are several species of the streamlined genera Cladoselache. Diademodus, Stethacanthus, Ctenacanthus. Orodus (Hansen, M. C. These Devonian sharks looked very different than extant sharks. To the untrained eye, they. It is from the famous Red Hill locality in Pennsylvania. One of the many casualties of this mass extinction was the Placoderms (armored fish). Armored fish were the prevailing class of fish; Placoderms included the Devonians top predator, the 2. Dunkleosteus. The extinction of this top class of predators left a large ecological hole. Immediately afterward, in the Carboniferous period, sharks seized the opportunity and became the top predators. The Carboniferous (Pennsylvanian and Mississippian epochs) marks the high watermark of sharks. Although the Carboniferous is known for it's huge coal forests and the radiation of amphibians, it is also known as the . A famous limestone bed in this formation is called the Bear Gulch Limestone found in Fergus County, Montana. This lagerstatte contains one of the world's most diverse fish assemblages. It includes over 6. Lund & Grogan 2. Some specimens even have skin pigments and internal organs preserved (Grogan & Lund 1. During this Golden Age, sharks were at their highest diversity; there was a profuse amount of families, genera. They came in all shapes and sizes, from a few inches to over 2. Some lived in freshwater. Some were beginning to look like modern sharks, while others took on unique. Some examples include the large whorl tooth shark, Helicoprion, which had replacement. The shark Belantsea Montana looked more like a fancy tropical aquarium fish than a. The entire Stethacanthus genus had a large anvil shaped dorsal fin, unlike anything that exists today. Sharks were still diverse, just not as diverse as in the Carboniferous. However, this all came to an abrupt end at the end of the Permian. The end of the Permian is marked by . The common animals that. After the Paleozoic Era, there are no trilobites, eurypterids. The list goes on and on. Any surviving. life was severely reduced as 8. Benton et al 2. 00. Causes of this extinction are. The specific causes are still being debated. Whether it was the formation of Pangaea. Earth was wiped out. Life barely squeaked by this one. Sharks barely survived this extinction event. The few surviving taxa, both on land and sea radiated and diversified, creating new ecosystems. Although mammals make their appearance, reptiles were the main creatures to dominate these new ecosystems. They dominated the land, via dinosaurs. They dominated the air, via flying reptiles. They also dominated the seas with a new terrifying kind of animal, the Great marine reptiles. These sea monsters were fierce predators that ruled the Mesozoic oceans. The surviving sharks took a back seat to these terrifying beasts. Although sharks took a back seat to the Great marine reptiles, they continued to diversify. By the end of the second period in the Mesozoic era, the Jurassic. At the close of the Mesozoic era, the Cretaceous, a great mass extinction event. The Dinosaurs, flying reptiles, and great marine reptiles all disappeared. This allowed. sharks to, once again, become the top sea predators. Mammals went to the ocean (whales, dolphins, seals, etc..). As a result, the modern looking sharks grew. This period saw. the birth of the world's largest and most fearsome shark, the Megatooth shark. This beast originated in the Paleocene. Otodus genera, and slowly became larger and larger through time until the apex species emerged in the Miocene and Pliocene. Carcarocles Megalodon. Think of this giant Megatooth shark as a 6. Great White! Other sharks during this time period. A good example is the Giant White sharks (Cosmopolitodus). These are non- serrated, larger. Great Whites of today. Luckily, for humans, by the close of the Pliocene, the large sharks became. To learn more about the megalodon shark. Conclusion. The fragmentary fossil record shows that sharks originated sometime in the Ordovician. The fossil record also shows sharks have continually evolved and changed. Many shark designs, from freshwater forms, to sharks with bizarre shapes, and even giants, have come and gone. These adaptations have allowed sharks to survive every mass extinction event and thrive to the present day. One remarkable thing about nature is that we can go out and find these prehistoric remains. To find your own prehistoric shark fossils. Ecosystem remodelling among vertebrates at the Permian- Triassic boundary in Russia: Nature, v. Grogan, E. D. Soft tissue pigments of the Upper Mississippian chondrenchelyid, Harpagofututor volsellorhinus (Chondrichthyes, Holocephali) from the Bear Gulch Limestone, Montana, USA. Journal of Paleontology, v. Hansen, M. Feldmann and Merrianne Hackathorn. Ohio Division of Geological Survey Bulletin 7. Lund, Richard & Grogan Eileen. March 2. 0, 2. 01. Cloutier, and S. The oldest articulated chondrichthyan from the Early Devonian period. Sansom, I. J. Chondrichthyan- like scales from the middle Ordovician of Australia. Pelaontology, 5. 5 (2): 2. Sansom I. J, Smith M. M, Smith M. P. Scales of thelodont and shark- like fishes from the Ordovician of Colorado. Tajute- Talimaa V. Elegestolepis grossi gen. Zerina Johanson, Mikiko Tanaka, Natalie Chaplin, and Moya Smith. Keep in mind, I’m not a therapist or any other kind of health professional—just a guy who’s willing to tell it like it is. I simply want to give you the tools.How to Handle a Flirty Professor. You’ve got problems, I’ve got advice. This advice isn’t sugar- coated—in fact, it’s sugar- free, and may even be a little bitter. Welcome to Tough Love. You’ve got problems, I’ve got advice. This advice isn’t sugar- coated—in fact, it’s sugar- free, and. I simply want to give you the tools you need to enrich your damn lives. If for whatever reason you don’t like my advice, feel free to file a formal complaint here. Now then, let’s get on with it. I’m in college. My professor never really bothered me before, but now I’m starting to question him. I changed my hair to red one day and he complimented how nice it was even though I hated it. ![]() I have never seen him comment on anyone else’s appearance. A few days later I dressed up pretty fashionable and changed my hair back to black . Then, another time in class, I was talking to my friend and asked her to call me by my nickname. He overheard, asking me why I didn’t ask him to do that. I just told him I found no reason to, but ever since then he calls me by my nickname anyway. He also gave us a quiz and one of the questions asked what we thought he could do to make the class better. I said “one day out the week for tutoring would be nice.” Here’s where things get a little weird.. Recently, a new staff member started at Lifehacker. She booted up her brand-new, company-issued MacBook Pro, and went to plug in her EarPods to listen to some tunes. It’s hard enough raising a child with an alarming array of symptoms. It’s even harder when doctors can’t figure out what’s wrong. 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Thanks.” Remember, you’re not debating his intentions with him, you’re telling him how you feel about it, and as your teacher he needs to respect that—period. He may not be aware that he’s making uncomfortable. While you feel a little harassed, he may think you’re cool with it in his creeper brain. Until you say something, he’ll probably continue. Whatever you choose to do, keep a record of everything he says to you, and when. If you choose to ask him to stop, keep a record of that as well. That way you’ll have plenty of evidence in case this situation escalates and it needs to be taken to a higher power. You never know.. You might dress well, have a cool job, and be blessed with beauty, but flirting is where the real. Tell me, what’s troubling you? Is work getting you down? Are you having problems with a friend or a coworker? Is your love life going through a rough patch? Do you just feel lost in life, like you have no direction? Tell me, and maybe I can help. 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Perl 5. 6 / 5. 8 / 5. Author: Graham Barr < gbarr (at) pobox. Abstract: SASL Authentication framework. For installation, cut and paste in a DOS console: ppm install http: //www. Authen- SASL. ppdautobox. Version 2. 8. 3Perl 5. Author: chocolateboy < chocolate (at) cpan. Abstract: call methods on native types. For installation, cut and paste in a DOS console: ppm install http: //www. Version 2. 2. 9Perl 5. Author: Paul Fenwick < pjf (at) cpan. Abstract: Replace functions with ones that succeed or die with lexical scope. For installation, cut and paste in a DOS console: ppm install http: //www. Auto. Loader. Version 5. Perl 5. 6 / 5. 8 / 5. Author: Steffen Mueller < smueller (at) cpan. Abstract: load subroutines only on demand. For installation, cut and paste in a DOS console: ppm install http: //www. Auto. Loader. ppd. Author: Florian Ragwitz < rafl (at) debian. Abstract: Execute code after a scope finished compilation. For installation, cut and paste in a DOS console: ppm install http: //www. B- Hooks- End. Of. Scope. ppd. Author: Florian Ragwitz < rafl (at) debian. Abstract: Wrap OP check callbacks. For installation, cut and paste in a DOS console: ppm install http: //www. B- Hooks- OP- Check. Author: Florian Ragwitz < rafl (at) debian. Abstract: Invoke callbacks on construction of entersub OPs for certain CVs. For installation, cut and paste in a DOS console: ppm install http: //www. B- Hooks- OP- Check- Entersub. For. CV. ppd. Author: Florian Ragwitz < rafl (at) debian. Abstract: Hook into opcode execution. For installation, cut and paste in a DOS console: ppm install http: //www. B- Hooks- OP- PPAddr. Author: Florian Ragwitz < rafl (at) debian. Abstract: Interface to perl's parser variables. For installation, cut and paste in a DOS console: ppm install http: //www. B- Hooks- Parser. B: :Keywords. Version 1. Perl 5. 6 / 5. 8 / 5. Author: Joshua ben Jore < jjore (at) cpan. Abstract: Lists of reserved barewords and symbol names. For installation, cut and paste in a DOS console: ppm install http: //www. B- Keywords. ppd. B: :Lint. Version 1. Perl 5. 8 / 5. 1. Author: Joshua ben Jore < jjore (at) cpan. Abstract: Perl lint. For installation, cut and paste in a DOS console: ppm install http: //www. B- Lint. ppd. Author: Josh Jore < jjore (at) cpan. Abstract: Apply strict to classes and methods. For installation, cut and paste in a DOS console: ppm install http: //www. B- Lint- Strict. OO. B: :Utils. Version 0. Perl 5. 6 / 5. 8 / 5. Author: Josh Jore < jjore (at) cpan. Abstract: Helper functions for op tree manipulation. For installation, cut and paste in a DOS console: ppm install http: //www. B- Utils. ppd. Author: Dagfinn Ilmari Mannsaker < ilmari (at) ilmari. Abstract: disables bareword filehandles. For installation, cut and paste in a DOS console: ppm install http: //www. Version 0. 4. 1Perl 5. Author: Tels, Peter John Acklam < pjacklam (at) gmail. Abstract: Transparent Big. Number support for Perl. For installation, cut and paste in a DOS console: ppm install http: //www. Bit: :Vector. Version 7. Perl 5. 6 / 5. 8 / 5. Author: Steffen Beyer < sb (at) engelschall. Abstract: Efficient bit vector, set of integers and ``big int'' math library. For installation, cut and paste in a DOS console: ppm install http: //www. Bit- Vector. ppdboolean. Version 0. 4. 6Perl 5. Author: Ingy dot Net < ingy (at) cpan. Abstract: Boolean support for Perl. For installation, cut and paste in a DOS console: ppm install http: //www. Boulder. Version 1. Perl 5. 6 / 5. 8 / 5. Author: Lincoln D. Stein < lincoln. Abstract: An API for hierarchical tag/value structures. For installation, cut and paste in a DOS console: ppm install http: //www. Boulder. ppd. Bread: :Board. Version 0. 3. 3Perl 5. Author: Stevan Little < stevan (at) iinteractive. Abstract: A solderless way to wire up your application components. For installation, cut and paste in a DOS console: ppm install http: //www. Bread- Board. ppd. Author: David Oswald < davido (at) cpan. Abstract: Perl extension to generate cryptographically- secure random bytes. For installation, cut and paste in a DOS console: ppm install http: //www. Bytes- Random- Secure. Canary: :Stability. Version 2. 00. 6Perl 5. Author: Marc A. Lehmann < cpan (at) schmorp. Abstract: canary to check perl compatibility for schmorp's modules. For installation, cut and paste in a DOS console: ppm install http: //www. Canary- Stability. Capture: :Tiny. Version 0. Perl 5. 8 / 5. 1. Author: David Golden < dagolden (at) cpan. Abstract: Capture STDOUT and STDERR from Perl, XS or external programs. For installation, cut and paste in a DOS console: ppm install http: //www. Capture- Tiny. ppd. Carp. Version 1. 3. Perl 5. 8 / 5. 1. Author: Andrew Main < zefram (at) fysh. Abstract: alternative warn and die for modules. For installation, cut and paste in a DOS console: ppm install http: //www. Carp. ppd. Carp: :Clan. Version 6. 0. 4Perl 5. Author: Steffen Beyer < STBEY (at) cpan. Abstract: Report errors from perspective of caller of a . Stein < lstein (at) cshl. Lee Johnson < lee (at) givengain. Abstract: Handle Common Gateway Interface requests and responses. For installation, cut and paste in a DOS console: ppm install http: //www. CGI. ppd. Check: :ISAVersion 0. Perl 5. 8 / 5. 1. Author: Yuval Kogman < nothingmuch (at) woobling. Abstract: DWIM, correct checking of an object's class. For installation, cut and paste in a DOS console: ppm install http: //www. Check- ISA. ppd. Class: :Accessor. Version 0. 3. 4Perl 5. Author: Marty Pauley < marty+perl (at) kasei. Abstract: Automated accessor generation. For installation, cut and paste in a DOS console: ppm install http: //www. Class- Accessor. ppd. Author: Hartog C. Black, < blblack (at) gmail. Abstract: XS speedups for Class: :C3. For installation, cut and paste in a DOS console: ppm install http: //www. Class- C3- XS. ppd. Author: Tony Bowden < tony (at) tmtm. Abstract: Inheritable, overridable class data. Cisco Scale- Up Solution for SAP HANA with the Cisco C8. M4 Server. Design and Deploy a SAP HANA Single- Node Solution Based on Cisco C8. M4 Servers with SUSE Linux Enterprise Server 1. SAP SP1. April 2. Executive Summary. Solution Overview. Introduction. Audience. Purpose of This Document. Solution Summary. Infrastructure Overview. Cisco C8. 80 M4 Server. Power Cabling. Network Components. Solution Design. SAP HANA System. Hardware Requirements for the SAP HANA Database. SAP HANA File System Layout. Operating System. Deployment Hardware and Software Configuration Guidelines. Preparing the SAP HANA Scale- Up Node. Configure the Cisco IMC for the Cisco C8. M4 Server. Connect to the Management Board. Set the Cisco IMC IP Address. Log in to the Web User Interface. Configure Cisco C8. M4 IMC Settings. Configure Cisco C8. M4 BIOS CPU Settings. Configure Cisco C8. M4 BIOS Memory Settings. Configure Cisco C8. M4 BIOS EFI Boot Settings. Configure Cisco C8. M4 BIOS Disk (RAID) Settings for the SAP HANA File System. Configure RAID 5 for SAP HANAInstalling the Operating System. Boot from OS Installation Media. Start the OS Installation for SAP HANAPartition the Disk for the Cisco C8. M4 Intel Broadwell–Based SAP HANA Appliance. Create the Boot File Partition. Create the Volume Group for SAP HANAConfigure the Time Zone. Set the Root User Password. Select the Package for the Installation. Disable the Firewall and Kernel Dump. Set the Default Systemd Target and Run Level. Install the Operating System. OS Post- Installation Tasks. Start and Register the System. Create Logical Volumes and File Systems for SAP HANACheck the /etc/hosts File. Set Up Network Time Protocol Service. Create High Availability for the Network. Performance Tuning Parameters for SAP HANATune the /etc/init. File. Tune the sysctl. Conf File. Disable C- States: Add Parameter to the Bootloader. Reboot the Appliance. Patching the Appliance. Register the System for Patching. Patch SLES for SAP Applications SP1. Reboot the Appliance. Installing SAP HANAImportant SAP Notes. SAP HANA In- Memory Database (IMDB) Notes. Linux Notes. SAP Application Notes. Third- Party Software Notes. SAP HANA Virtualization Notes. SAP HANA Post- Installation Checkup. SAP HANA Post- Installation Tasks. Check the SAP HANA Services. Check the HANA Database Information. Maintain the Operating System. Prerequisites. Updating the OS and Kernel. Updating SUSE and the Kernel Online. Option 1: Using Ya. STSAP HANA Operation and Maintenance. Monitoring SAP HANAStarting and Stopping SAP HANADownloading Revisions. For More Information. Appendix: Solution Variables Used for This Document. Executive Summary. Organizations in every industry are generating and using more data than ever before: from customer transactions and supplier delivery details to real- time user- consumption statistics. Without reliable infrastructure that can store, process, and analyze big data sets in real time, companies cannot use this information to their advantage. With eight Intel. The reference architecture detailed in this document highlights the resiliency and ease of deployment of a SAP HANA solution. SAP HANA is SAP’s implementation of in- memory database technology. The SAP HANA database takes advantage of the low- cost main memory (RAM), faster access, and data- processing capabilities of multicore processors to provide better performance for analytical and transactional applications. SAP HANA offers a multiple- engine query- processing environment that supports relational data (with both row- and column- oriented physical representations in a hybrid engine) as well as graph and text processing for semistructured and unstructured data management within the same system. As an appliance, SAP HANA combines software components from SAP optimized for certified hardware. However, this solution has a preconfigured hardware setup and preinstalled software package that is dedicated to SAP HANA. In 2. 01. 3, SAP introduced the SAP HANA Tailored Datacenter Integration (TDI) option. TDI offers a more open and flexible way to integrate SAP HANA into the data center by reusing existing enterprise storage hardware, thereby reducing hardware costs. With the introduction of SAP HANA TDI for shared infrastructure, the Cisco UCS. The TDI option enables organizations to run multiple SAP HANA production systems on a shared infrastructure. It also enables customers to run SAP application servers and SAP HANA databases hosted on the same infrastructure. For more information about SAP HANA, see the SAP help portal: http: //help. Audience. The intended audience for this document includes sales engineers, field consultants, professional services staff, IT managers, partner engineers, and customers deploying the Cisco solution for SAP HANA. External references are provided wherever applicable, but readers are expected to be familiar with the technology, infrastructure, and database security policies of the customer installation. Purpose of This Document. This document describes the steps required to deploy and configure a Cisco data center solution for SAP HANA. This document showcases one of the variants of Cisco’s solution for SAP HANA. Although readers of this document are expected to have sufficient knowledge to install and configure the products used, the document provides configuration details that are important to the deployment of this solution. Solution Summary. The Cisco Scale- Up Solution for SAP HANA is based on the Cisco C8. M4 Server. Tables 1, 2, and 3 summarize the server specifications and show proposed disk configurations for the SAP HANA use case. Therefore, power supplies must be connected to one grid, and the server tolerates the failure of one power supply. However, a grid failure is not protected. To protect against a grid failure, each power supply must be connected to a completely separate grid connection. This setup is the preferred installation and is recommended to the customer. Table 4 shows the power supply requirements and redundancy. Table 4. This board includes virtual keyboard, video, and mouse (KVM) access at the hardware level (Figure 4). Figure 4. SAP HANA System. An SAP HANA scale- up system on a single server is the simplest of the installation types. It is possible to run an SAP HANA system entirely on one host and then scale the system up as needed. All data and processes are located on the same server and can be accessed locally. The network requirements for this option are at least one 1 Gigabit Ethernet access network and one 1. Gigabit Ethernet storage network. Hardware Requirements for the SAP HANA Database. SAP defines hardware and software requirements for running SAP HANA systems. For the latest information about the CPU and memory configurations supported for SAP HANA, refer to https: //global. EN/index. html. Note: This document does not cover the updated information published by SAP. Additional information is available at http: //saphana. SAP HANA File System Layout. Figure 5 shows the file system layout and the required storage sizes for installing and operating SAP HANA. When installing SAP HANA on a host, specify the mount point for the installation binary files (/hana/shared/< sid> ), data files (/hana/data/< sid> ), and log files (/hana/log/< sid> ), where sid is the instance identifier of the SAP HANA installation. In this process, various steps require you to insert customer- specific naming conventions, IP addresses, and VLAN schemes, as well as to record appropriate MAC addresses. Table 6 lists the configuration variables that are used throughout this document. This table can be completed based on the specific site variables and used in implementing the configuration steps presented in this document. These two ports work as clustered ports (Figure 6). Figure 6. During the initialization process, verify that the MMB RDY LED flashes and that the Alarm LED of the unit in the front is on. Enter the login name Administrator. This is a preset default administrator user account name. DNA Homepage - - Nucleic Acid Structures. The DSSR- Jmol paper, titled . Notably, the work has been featured in the cover image, as shown below: Caption: 3. D interactive visualization of selected RNA structural features enabled by the DSSR- Jmol integration (http: //jmol. Clockwise from upper left: Structure of the xpt- pbu. X guanine riboswitch in complex with hypoxanthine (PDB id: 4fe. The three- way junction loop encompassing the metabolite (in space- filling representation) is color- coded by base identity: A, red; C, yellow; G, green; U, cyan. The loop- loop interaction (a kissing- loop motif) at the top is highlighted in red (upper left corner). Structure of the Thermus thermophilus 3. S ribosomal subunit in complex with antibiotics (PDB id: 1fjg) in step diagram. The 1. 6S ribosomal RNA is color- coded in spectrum with the 5. Structure of the classic L- shaped yeast phenylalanine t. RNA (PDB id: 1ehz) in step diagram, with the three hairpin loops highlighted in red and the . Structure of the Pistol self- cleaving ribozyme (PDB id: 5ktj), showcasing (in red) the horizontal helix in space- filling representation. The helix is composed of six short stems stabilized via coaxial stacking interactions (bottom). The DSSR- Jmol integration bridges the DSSR command- line analyzing tool and the Jmol molecular viewer seamlessly together via the standard JSON interface. Now users can select DSSR- derived RNA structural features (such as base pairs, double helices, various loops, etc.) and visualize them in novel representations in Jmol interactively. Moreover, fine- grained characteristics of these features can be queried via the Jmol SQL for DSSR. The DSSR- Jmol integration fills a gap in RNA structural bioinformatics, and brings RNA visualization to an entirely new level. The web interface (http: //jmol. Featured as the cover image of the 2. NAR web- server issue, DSSR's publicity would surely increase through the DSSR- Jmol integration. Additionally, I've written a new post (on the 3. DNA Forum) that provides the scripts and datafiles used to create the cover image. I am pleased to announce the (advance online, May 3, 2. Co- authored by Robert Hanson (Jmol) and me (DSSR), the article will appear in the July 2. NAR. Here are the key links related to the paper: The DSSR- Jmol integration project was initiated in October 2. I approached Bob at a meeting organized by RCSBPDB at Rutgers. Thereafter, we met only once in July 2. A free multi-format, cross-platform video editor designed for simple cutting, filtering and encoding tasks. Available for Windows, Mac OS and Linux. SIB resources External resources - (No support from the ExPASy Team) Databases. SWISS-MODEL Repository Name Type Description Manufacturer Location Keywords; SPSS: Statistical A statistical Package, designed for analysing data. IBM SPSS: Staff WTS 2000 Cluster WTS. This tuto explains how to install and compile the last version of Pymol on Windows and Linux. News : updated to 1.8.2.0 for 64bit systems on 25/04/16 Windows. This is the RasMol, RasWin and RasMac Home Page visited by more than 650,000 people. Look here for current releases. 2016-12-31: 2.6.16 : BugFixes * Build : Avidemux can be built with visual c++ 2015 (losing some ASM) * OsX : Initialize fontconfig so that subtitling works. Paris. Over the years, we have mostly communicated via email, occasionally facilitated by Skype. Our work bridges the DSSR command- line analyzing tool and the Jmol molecular viewer together via a simple JSON interface and a powerful query language. Users can now select DSSR- derived RNA structural features (such as base pairs, double helices, and various loops) as easily as they can select protein alpha- helices and beta- strands. Download apps about Education for windows like mecanet, typingmaster, hot potatoes. SIB resources External resources - (No support from the ExPASy Team) Databases. ![]() Moreover, fine- grained characteristics of these features can be queried via Jmol SQL for DSSR (see examples below). Notably, the novel representation styles (step diagram and base blocks) and coloring schemes bring RNA visualization to an entirely new level (see Figure 3 of the paper). RNA to Jmol with DSSR annotation. SELECT hairpins # select the three hairpin loops. SELECT junctions # select the four- way junction loop. Its functionality is freely accessible either via the Jmol application, or the JSmol- based website (http: //jmol. By adhering to web standards, the website is fully functional in all modern browsers on various computer/operating systems (including handheld devices, such as tablets and smart phones). The web interface is simple and intuitive, and new users can get started easily. It also allows power users to take full advantage of Jmol scripting via a command- line console. This work also provides an example for integrating DSSR- derived features into other molecular graphics programs or bioinformatics pipelines involving nucleic acid structures. By design, DSSR is a stand- alone, command- line program written in ANSI C. The binary executables are only ~1. MB in size, and self- contained. With zero dependencies, no setup or configuration, it is trivial to get DSSR up and running. DSSR uncovers a wide range of RNA/DNA structural features in a consistent, easily accessible framework. It possesses a much richer set of functionalities for nucleic acid structural analysis (see the DSSR User Manual) than any other existing tools I am aware of. Moreover, the program is efficient and robust, making it an ideal component to be integrated into other pipelines, especially via the standard and structured JSON interface. Collaborating with Bob has been a truly exciting experience. The NAR- web publication represents a gratifying intermediate result along an on- going journey. Hopefully, others (may be some of you) can join us in pushing forward the field of RNA structural bioinformatics. Recently, while analyzing a representative set of RNA structures from the PDB, I came across three weird entries. They are documented below, primarily for my own record. Structure of the KH domain of T- STAR in complex with AAAUAARNA”. There are two alternative conformations for the six- nt AAAUAARNA component, labeled A and B, respectively. Normally, the A/B alternative coordinates for each atom are put directly next to each other, and assigned the same chain id, as in 1msy for the phosphate group of G2. ![]() A. In 5els, however, the two alternative conformations (A/B) are separated into two chains: chain H for A, and chain I for B. The structure of the transition state analogue . The three- nt fragment DA1. C1. 80—C1. 81 on chain 4 is in the 3’—> 5’ direction. The crystal structure of m(6)A RNA with the YTHDC1 YTH domain”. The mm. CIF file has a model number of 0, instead of 1 (as in other cases I am aware of). Dear 3. DNA Forum subscribers,Note: If you’ve difficulty in accessing the 3. DNA homepage, possibly the case from mainland China (as I know it), please visit its duplicate at http: //home. This newsletter is written in Markdown, with a translated HTML version posted on the 3. DNA homepage. 3. DNA v. The C source code is now available. Since the programs are written in strict ANSI C, 3. DNA can be compiled (as is) on any computers/operating systems with a C (or C++) compiler. For user convenience, three binary distributions (with source code under the src/ subdirectory) are provided for Windows, Linux, and Mac OS X. The distributed Windows version works in native Windows (7 and up, via the cmd command- line interface, or Con. EMU), Min. GW/Msys (Msys. Cygwin, in either 3. A new set of . See the short communication titled Characterization of base pair geometry in the January 2. Computational Crystallography Newsletter (CCN). The fiber program includes a new option, - -pauling, for easy generation of Pauling & Corey triplex models of DNA/RNA with arbitrary base sequence. See my blogpost titled Pauling’s triplex model of nucleic acids is available in 3. DNA. Thomas Holder (Py. MOL Principal Developer at Schr. Now generating standard, regular DNA/RNA models in Py. MOL is straightforward — thanks, Thomas! DSSR (Dissecting the Spatial Structure of RNA)Selected features of DSSR have been incorporated into Jmol (in collaboration with Robert Hanson, Jmol Principal Developer), and Py. MOL (in collaboration with Thomas Holder). In Jmol application (via the Console window), one can now, for example, load =1ehz/dssr and then select hairpins; color red to see where the three hairpin loops are in 3. D. The Jmol- DSSR web interface makes DSSR- enhanced visualization of nucleic acid structures in Jmol readily accessible to a broad user base, and has been employed in classes for educational purpose. A sample image of DSSR- derived cartoon- block representation via Py. MOL is available for PDB entry 5dww, which has a G- quadruplex- duplex interface. Since the publication of the Nucleic Acids Research paper in 2. DSSR has been continuously refined and expanded, with a total of 3. Utilizarea dispozitivului criptografic (token) . Pentru utilizarea acestuia trebuie instalate driver- ele primite pe CD. Ghidul de instalare a certificatului digital si driver- ele pentru token- urile Oberthur sunt disponibile pe CD. Pagina 1 din 5 Procedura de reinnoire a certificatului digital la portalul ANAF Versiunea 1.3 Aceste instructiuni descriu etapele necesare pentru a va putea reinnoi. CertSIGN furnizeaz. ACCESUL CONTROLAT LA DOSARUL FISCAL. SCOPUL ACESTUI MANUAL Aceste instruc Descarca Declaratii fiscale actualizate la zi. Pentru a descarca declaratii fiscale dati clic dreapta pe declaratie si apoi save as sau save link as. ![]() Instalarea acestora din urma se face urmand pasii descrisi in ghid. In cazul in care, dupa instalarea driverelor, exista dificultati in utilizarea dispozitivului criptografic, trebuie identificata care dintre situatiile de mai jos este intalnita. Situatia 1: Dispozitivul nu apare in My Computer. Rezolvare: Dispozitivul criptografic nu este un stick de memorie, nu trebuie sa apara in My Computer. Dispozitivul este accesat direct de catre aplicatii, in momentul crearii semnaturii electronice, sau prin intermediul programelor furnizate de catre producatorul dispozitivului. Situatia 2: Dupa instalare, dispozitivul criptografic nu poate fi accesat. Dupa instalare, atunci cand se doreste accesarea dispozitivului criptografic sau la schimbarea codului PIN apare: Rezolvare: Se verifica sa fie tokenul introdus in unitate si ledul de pe token aprins apoi se da click dreapta pe My Computer, se alege Manage. Se alege Device Manager. Se verifica in lista de componente sa apara On Chip Security USB, ca in imaginea de mai jos. Daca apare asa: Se da click dreapta pe USB Smart Chip Device si se seleteaza Uninstall. Se apasa OK la mesajul de avertizare care apare, se scoate tokenul din unitate si se verifica din nou. Daca apare tot ca in pozele de mai sus e verifica sa fie drivere- le instalate. Daca On Chip Security USB driver apare corect, se verifica functionarea serviciul de smart card. Din fereastra din care s- a ales Device Manager se alege Services and Applications apoi Services, ca in imaginea de mai jos: Se cauta serviciul de smart card (sunt aranjate in ordine alfabetica)Se da dublu click pe serviciu apoi se verifica sa fie configurat ca in imaginea de mai jos. Startup type: Automatic (daca este Manual se da click pe Manual si se alege Automatic)Service status: Started (daca este Stoped se apasa butonul Start) apoi se da OK. Se verifica in aplicatia de Management sa ceara codul PIN (passphrase)Se introduce codul PIN si se verifica daca certificatul este pe token: Se verifica daca certificatul apare in Internet Explorer. Se deschide o pagina de Internet Explorer se alege Tools apoi Internet Options. De aici se alege Content apoi se pasa butonul Certificates. Daca certificatul nu se afla in . |
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